Earlier this year, Dow component UnitedHealth (NYSE: UNH), IHF’s largest holding at a weight of 13.4%, agreed to acquire Catamaran for $12.8 billion in cash.

In 2009, Express Scripts (NasdaqGM: ESRX) spent $4.7 billion to acquire WellPoint and followed up that deal with the $29 billion acquisition of Medco in 2012. [Healthcare ETFs Remain Sturdy]

Last month, shares of Quest Diagnostics (NYSE: DGX), the provider of healthcare diagnostic testing services, after it was rumored that that company could be a takeover target as well though chatter to that effect has since ebbed. Quest Diagnostics is 2.6% of IHF and 2% of XHS.

Investors have poured a combined $258.55 million into IHF and XHS this year.

iShares U.S. Healthcare Providers ETF